An Overview on Biochemical Parameters and Organ Injury in COVID-19 Patients
Sarita A. Shinde *
Department of Biochemistry, Pad. Dr. D.Y. Patil Medical College, Hospital and Research Center, Dr. D.Y. Patil Vidypeeth (DPU), Pimpri, Pune, India.
Vaishali V. Dhat
Department of Biochemistry, Pad. Dr. D.Y. Patil Medical College, Hospital and Research Center, Dr. D.Y. Patil Vidypeeth (DPU), Pimpri, Pune, India.
Pradnya J. Phalak
Department of Biochemistry, Pad. Dr. D.Y. Patil Medical College, Hospital and Research Center, Dr. D.Y. Patil Vidypeeth (DPU), Pimpri, Pune, India.
Umesh K. More
Department of Biochemistry, Pad. Dr. D.Y. Patil Medical College, Hospital and Research Center, Dr. D.Y. Patil Vidypeeth (DPU), Pimpri, Pune, India.
Anita D. Deshmukh
Department of Biochemistry, Pad. Dr. D.Y. Patil Medical College, Hospital and Research Center, Dr. D.Y. Patil Vidypeeth (DPU), Pimpri, Pune, India.
Mona A. Tilak
Department of Biochemistry, Pad. Dr. D.Y. Patil Medical College, Hospital and Research Center, Dr. D.Y. Patil Vidypeeth (DPU), Pimpri, Pune, India.
*Author to whom correspondence should be addressed.
Abstract
The Coronavirus disease (COVID-19) is considered as a respiratory disease which can cause a multi-organ injury like acute cardiac injury, kidney injury, and liver dysfunction. COVID-19 patients had The different of blood biochemical abnormalities where found in covid -19 patients which might indicate multiple organ dysfunction.
Hence the aim of the present study is provision of overview on organ injury and changes in biochemical parameters in Covid-19 patients.
The common laboratory abnormalities in COVID-19 patients included elevated inflammatory markers like CRP, ferritin, procalcitonin, cytokines and IL-6, IL-2, IL-7 and elevated prothrombin time and D-dimer. The cardiac injury is shown by increased concentration of CK-MB, LDH, and cTn and brain natriuretic peptide (BNP).
In liver and kidney dysfunction mild or moderate elevation of AST, ALT, total bilirubin, ALP, GGT, hypoalbuminemia, blood urea, creatinine and electrolyte disturbances were seen.
Hence reviewing currently available data, the present study can suggest that monitoring of the biochemical parameters may help in prediction of organ damage which further can prevent disease progression early interventions.
Keywords: 2019 novel coronavirus, COVID-19, biochemical parameters, interleukins