Promiscuous Bioactivty of Phytochemicals
Ogochukwu Jennifer Umezinwa
Department of Science Laboratory Technology, Faculty of physical sciences, University of Nigeria, Nsukka, Nigeria.
Muhammad Alfa Ma’ali
Department of Plant Biology, Federal University of Technology, Minna, Niger state, Nigeria.
Mohammed Yakubu Manbe
Department of Animal Biology, Federal University of Technology, Minna, Niger state, Nigeria.
Ugwu Obiora Celestine
Department of Pharmacology, Faculty of Pharmaceutical Sciences, Enugu State University of Science and Technology, Nigeria.
Nwankwo Ukechi Joy
Department of Biochemistry, Faculty of Biological Sciences, University of Nigeria, Nsukka, Nigeria.
Augustine Odibo
Department of Pharmacology, Univeristy of Benin, Nigeria.
Abdullahi Alausa
*
Department of Biochemistry, Ladoke Akintola University of Technology, Ogbomoso, Nigeria.
*Author to whom correspondence should be addressed.
Abstract
Phytochemicals are broad, largely studied compounds isolated from plants, generally regarded as a research compound than a nutritive molecule. In recent times, the pharmaceutical industry employs plants in the synthesis of novel drugs and active ingredients. These drugs and ingredients effectively manage neurodegenerative disorders, metabolic diseases, cancer, obesity, and other chronic-degenerative diseases. Although it still remains to be elucidated, the therapeutic strategies in synthesizing novel compounds. In this review, we discuss the major classification of phytochemicals, in addition to its biochemical mechanism of action. Furthermore, this study detailed the biosynthetic cascade of various phytochemicals and explained the anti-inflammatory and antioxidant mechanism on various disease processes. Therefore, this review discusses the multifunctional bioactivity of phytochemicals.
GRAPHICAL ABSTRACT
Keywords: Phytochemicals, COVID-19, neurodegenerative disease, cancer, obesity