Evaluation of Anti-diabetic and Antioxidant Properties of Ethanol Leaf Extract of Jathropha tanjorensis

Obioha Kennedy Chinonye

Department of Pediatrics, Federal Medical Centre, Owerri, Imo State, Nigeria.

Amah Akuma Kalu *

Department of Human Physiology, Imo State University, Owerri, Nigeria.

Elendu Melford Uche

Department of Human Physiology, Imo State University, Owerri, Nigeria.

Iheukwumere Chinedu Barry

Department of Human Physiology, Faculty of Basic Medical Sciences, Abia State University, Uturu, Nigeria.

*Author to whom correspondence should be addressed.


The aim of this study was to evaluate the anti-diabetic and antioxidant properties of ethanol leaf extract of Jathropha tanjorensis. Freshly harvested leaves of Jathropha tanjorensis were thoroughly processed into extract. Twenty five (25) adult male wistar rats were divided into five groups of five rats each. Group I was the normal control allowed unrestricted access to food and water only. Group II was the negative control and was induced with diabetes without treatment, Groups III and IV were diabetic rats administered with ethanol leaf extract of Jathropha tanjorensis, while Group V was diabetic rats administered with the standard drug. After treatment had been concluded, animals were sacrificed and blood and tissue obtained were analyzed using standard procedures. A significantly (P<0.05) high blood sugar level was reported for diabetic rats which however was significantly (P<0.05) reversed with oral administration of ethanol leaf extract of Jathropha tanjorensis in a dose dependent manner. The activity of the liver antioxidant enzymes was significantly (P<0.05) reduced in diabetic rats which however was significantly (P<0.05) increased following oral administration of Jathropha tanjorensis leaf extract in a dose dependent manner across treatment periods. In conclusion, the study unveils the antidiabetic and antioxidant potential of J. tanjorensis leaf.

Keywords: Jathropha tanjorensis, antioxidant enzymes, anti-diabetic, diabetes, liver

How to Cite

Chinonye, Obioha Kennedy, Amah Akuma Kalu, Elendu Melford Uche, and Iheukwumere Chinedu Barry. 2022. “Evaluation of Anti-Diabetic and Antioxidant Properties of Ethanol Leaf Extract of Jathropha Tanjorensis”. Asian Journal of Biochemistry, Genetics and Molecular Biology 12 (4):10-14. https://doi.org/10.9734/ajbgmb/2022/v12i4267.


Download data is not yet available.


Wild S, Roglic G, Green A, Sicree R, King H. Global prevalence of diabetes: Estimates for the year 2000 and projections for 2030. Diabetes Care. 2004; 27(05):1047-1053.

Long L, Wang J, Lu X, Xiaofang L, Yuxia X, Shuhui Z, Canqiao L, Yubin L. Protective effects of scutellarin on type II diabetes mellitus-induced testicular damages related to reactive oxygen species/Bcl-2/Bax and reactive oxygen species/microcirculation/ staving pathway in diabetic rat. J Diabetes Res. 2015; 252530.

Saidu AN, Mann A, Onuegbu CD. Phytochemical screening and hypoglycemic effect of aqueous Blighiasapida root bark extract on normoglycemic albino rats. Br. J. Pharm. Res.2012;156:357-361.

Giugliano D, Marfella R, Coppola L, Verrazzo G, Acampora R, Giunta R, Nappo F, Lucarelli C, D’Onofrio F. Vascular effects of acute hyperglycemia in humans are reversed by LArgenine. Circ. 1997;95:1783-1790.

Omobuwajo OR, Alade GO, Akanmu MA, Obutor EM, Osasan SA. Microscopic and toxicity studies on the leaves of J. tanjorensis. Afr J Pharm Pharmacol. 2011; 5(1):12-17.

Omoregie ES, Osagie AU. Phytochemical screening and antianaemic effect of Jatropha tanjorensis leaf in protein malnourished rats. Plants Arch. 2007; 7:509-516.

Omoregie ES, Sisodia BS. In vitro antiplasmodial activity and cytotoxicity of leaf extracts from J. tanjorensis. Pharmacology Online. 2011;2:656-673.

Lorke D. A new approach to practical acute toxicity testing. Arch Toxicol.1983; 54(4):275-287.

Burcelin R, Eddouks M, Maury I, Kande J, Assan R, Girard J. Excessive glucose production, rather than Insulin resistance, account for hyperglycemia in recent onset streptozotocin-diabetic rats. Diabetologia. 1995;35:283-290.

Sinha AK. Colorimetric assay of catalase. Anal Biochem.1972;47:389-394.

Ugochukwu NH, Babady NE, Cobourne M, Gasset SR. The effect of Gangronemalatifolium extracts on serum lipid profile and oxidative stress in hepatocytes of diabetic rats. J. Biosci. 2003;28(1):1-5.

Unwin N, Sobngwi E, Alberti KGMM. Type 2 diabetes: The challenge of preventing a global epidemic. Diabetes Int. 2001;4-8.

Boussageon R, Bejan-Angoulvant T, Saadatian-Elahi M, Lafont S, Bergeonneau

C, Kassaï B et al. Effect of intensive glucose-lowering treatment on all cause mortality, cardiovascular death, and microvascular events in type 2 diabetes mellitus: A meta-analysis of randomized controlled trials. Brit Med J. 2011;343: d4169.

Asuk AA, Dasofunjo K, Okafor AI, Mbina FA. Antidiabetic and antioxidative effects of Jatropha curcas extracts in streptozotocin-induced diabetic rats. BJMMR. 2015;5(3):341-349.

Matough FA, Budin SB, Hamid ZA, Alwahaibi N, Mohamed J. The role of oxidative stress and antioxidants in diabetic complications. Squ Med J. 2012; 12(1):5-18.