Association of Apolipoprotein A Gene Polymorphism with Uncomplicated Plasmodium falciparum Malaria in Elfasher City, North Darfur, Sudan
Alaa Abdallah Adam Idrise
Department of Clinical Chemistry, Faculty of Medical Laboratory Science, Karary University, Khartoum, Sudan.
Amanda G. Elgoraish
Department of Epidemiology, Tropical Medicine Research Institute, National Centre for Research, Khartoum, Sudan.
Rania Tag Elsir Ahmed
Department of Epidemiology, Tropical Medicine Research Institute, National Centre for Research, Khartoum, Sudan.
Nadia Madni Mohamed Omer
Department of Clinical Chemistry, Faculty of Medical Laboratory Science, Karary University, Khartoum, Sudan.
Mohamed A. M. Salih
Department of Clinical Chemistry, Faculty of Medical Laboratory Science, Karary University, Khartoum, Sudan.
Jamal Ismail Khalifia Ismail
Faculty of Medicine, Elfasher University, Elfasher, Sudan.
Nassreldeen Khalid Abdelraman Adam
Department of Hematology, Faculty of Medical Laboratory Sciences, Elfasher University, Sudan and Al-Gharb College for Science and Technology, Nyala, South Darfur, Sudan.
Salaheldein G. Elzaki *
Department of Epidemiology, Tropical Medicine Research Institute, National Centre for Research, Khartoum, Sudan.
*Author to whom correspondence should be addressed.
Abstract
Aims: This study aimed to investigate the lipids profile, APOA genotype with malaria infection. It was hypothesized that the malaria parasite uses cholesterol and phospholipids from its host, resulting in a decrease in serum HDL.
Study Design: A cross-sectional hospital -based study.
Place and Duration of Study: The study was conducted during the transmission season between July to November 2020 in different hospitals and centers in Elfasher city.
Methodology: We included (39 men and 64 female), 57.3% were adults and 42.7% were children, plasmodium falciparum infection, with clinical symptoms and signs of uncomplicated malaria. Parasites density, lipids profile and APOA genotyping were assayed.
Results: The mean level of CHOL and TG was 134.7 mg/dl and 73.0 mg/dl, respectively, and the average levels of LDL and HDL are 56.6 mg/dl and 56.2 mg/dl, respectively. The G/G genotypes of APOA were identified in 94.2% of the patients compared to other APOA genotypes. The overall allele frequency for the G allele was 96.0%, and the T allele was 3.9% using the Hardy-Weinberg distribution.
Conclusion: In conclusions, the lipids profile and APOA genotype were not associated with uncomplicated malaria.
Keywords: Malaria, lipids, cholesterol, lipoproteins, high-density lipoprotein, low-density lipoprotein, triglycerides