Intracellular Protein Biosynthesis: A Review
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Abstract
Proteins are macromolecules made up of many amino acids that linked together by peptide bond to make a protein molecule. The sequence and the number of amino acids determines each protein unique structure and specific function. Proteins play a vital role in living systems and play important biological functions. Biosynthesis of protein occur in our body cells in order to support the biological function in our body. Intracellular protein synthesis is a complex process that involve the transformation of information and instructions from a genetic material DNA inside the nucleus to form mRNA molecules that transferred to the cytoplasm and liked to the cytoplasmic ribosome. Subsequently, the m RNA and further encode a sequence of amino acid in a specific order and number to form a polypeptide chains that finally undergoes conformational changes and folding to form a particular structure protein. This review will focus on the tow consecutive stages of protein biosynthesis; transcription and translation, and their substage processes; initiation, elongation, and termination. Briefly, overview the role of protein in the biological function and the different types of protein structure.
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References
Litwack G. Protein biosynthesis. In: Human Biochemistry. 2018;319–36.
Alves AC, Tavares GM. Mixing animal and plant proteins: Is this a way to improve protein techno-functionalities? Food Hydrocoll. 2019;97:105171.
Garcia-Torres R, Young L, Murray DP, Kheda M, Nahman NS. Dietary protein source and phosphate levels in patients on hemodialysis. J Ren Nutr [Internet]. 2020;1–7. Available:10.1053/j.jrn.2019.11.006
Clark DP, Pazdernik NJ, R.Michelle M. Protein synthesis. In: Molecular Biology. 2019;397–444.
Lengyel P, Söll D. Mechanism of protein biosynthesis. Bacteriol Rev. 1969;33(2):264–301.
Lucas-lenard J. Protein biosynthesis. Annu Rev Biochem. 1971;40(1):409–48.
Aryal S. Prokaryotic Transcription- Enzymes, Steps, Significance; 2018. Available:https://microbenotes.com/prokaryotic-transcription-enzymes-steps-significance/
LadyofHats. Ribosome mRNA translation.
Mazumder R, Ochoa S. Polypeptide chain initiation. In: The Enzymes. 1974;1–51.
Warren B. Translation of DNA. Available:https://teachmephysiology.com/biochemistry/protein-synthesis/dna-translation/
Lucas J, Beres L. Peptide chain elongation. In: The Enzymes. 1974;53– 86.
Caskey CT. Polypeptide chain termination. In: The Enzymes. 1974;78–118.
Yon JM. Protein folding: A perspective for biology, medicine and biotechnology. Brazilian J Med Biol Res. 2001;34(4):419–35.
Vaidyanathan K. Proteins: Structure and function. in: Textbook of biochemistry for medical students. 2016;38–55.
Hjorth CF, Norrman M, Wahlund PO, Benie AJ, Petersen BO, Jessen CM, et al. Structure, aggregation, and activity of a covalent insulin dimer formed during storage of neutral formulation of human insulin. J Pharm Sci. 2016;105(4):1376– 86.
Ma W, Tang C, Lai L. Specificity of trypsin and chymotrypsin: Loop-motion-controlled dynamic correlation as a determinant. Biophys J. 2005;89(2):1183–93.
Rashid MA, Khatib F, Sattar A. Protein preliminaries and structure prediction fundamentals for computer scientists. arXiv.org [Internet]. 2015;1–23. Available:http://arxiv.org/abs/1510.02775
Lipscomb WN, Kantrowitz ER. Structure and mechanisms of escherichia coli aspartate transcarbamoylase. Acc Chem Res. 2012;45(3):444–53.