Evaluation of the Antioxidant Properties of Vitellaria paradoxa Seed Extract and Its Effect of Ultra Violet Radiation Induced Skin Damage
Asian Journal of Biochemistry, Genetics and Molecular Biology,
Ultra violet radiation (UVR) is relevant in nature, but despite its importance it has been labeled as a causative agent in skin damage. This study was done to evaluate the antioxidant properties of shea butter and its role in the prevention of skin damage. Six groups of albino rats with three rats per group were used, group 2-5 were exposed to UVR at the dose of 180 mJ/cm2 with group 1 serving as the normal control, group 2 (negative control), group 2-5 (treated groups) and group 6 (normal + treated). The treatment was done by topical application of Vitellaria parodoxa seed extract 5 minutes after exposure to UVR. The in-vitro antioxidant properties determined using DPPH radical scavenging activity revealed that the aqueous extract of Vitellaria paradoxa possesses high antioxidant activity. There was an increase in the concentration of GSH of the treated animals when compared to the negative control (p<0.05). The histopathology result shows the extract had a protective effect on the skin tissue of the experimental animals. This study suggests the extract has the potential to serve as a chemopreventive agent against UV-induced skin damage by neutralizing the effects of free radicals generated by ultraviolet radiation and as such can be recommended for use as UVR screen which could in turn reduce the risk of UVR skin damage.
- Skin damage
- ultra violet radiation
- Vitellaria parodoxa (Shea butter)
How to Cite
Cuypers A, Plusquin M, Remans T, Jozefczak M, Keunen E, Gielen H. Cadmium stress: An oxidative challenge. Biometals. 2010;23:927–940.
Akihisa T, Kojima N, Kikuchi T, Yasukawa K, Tokuda H, Masters ET, Manosroi A, Manosroi J. Anti-inflammatory and chemopreventive effects of triterpenecinnamates and acetates from shea fat. Journal of Oleo Science. 2010; 59(6):273–280.
World Health Organization. Ultraviolet (UV) radiation and skin cancer; 2017.
Koh HK, Geller AC, Miller DR. Prevention and early detection strategies for melanoma and skin cancer: Current status. Archives of Dermatology. 1996;132(4):436-442.
Wang ZY, Huang MT, Ho CT, Chang R, Ma W, Ferraro T, Reuhl KR, Yang CS, Conney AH. Inhibitory effect of green tea on the growth of established skin papillomas in mice. Cancer Research. 1992;52(23):6657-6665.
Griffith OW. Determination of glutathione and glutathionedisulﬁde using glutathione reductase and 2-vinylpyridine. Analytical Biochemistry. 1980;106:207–212.
Lichterman BL. Aspirin: The Story of a Wonder Drug. British Medical Journal. 2004;329(7479):1408.
Schippmann U, Leaman DJ, Cunningham AB. Impact of Cultivation and Gathering of Medicinal Plants on Biodiversity; 2002.
Chowdhury WA, Arbee S, Debnath S, Bin Zahur SM, Akter S, Rezaul AKM, Mohammad MM, Abida T, Sagor MAT, Sarif Mohiuddin. Potent Role of Antioxidant Molecules in prevention and Management of Skin Cancer. Journal of Clinical and Experimental Dermatology Research. 2017;8:393.
Torres A. Response to ‘Avoidance of sun exposure as a risk factor for major causes of death: a competing risk analysis of the melanoma in Southern Sweden cohort’. Journal of internal medicine. 2017;281: 217-218.
Hault K, Rönch H, Beissert S, Knuschke P, Bauer A. Knowledge of outdoor workers on the effects of natural UV radiation and methods of protection against exposure. Journal of the European Academy Dermatology and Venereology. 2016;30: 34-37.
Kantivan PG, Mayuri S, Rashmi S. Scholars Academic Journal of Pharmacy (SAJP). 2013;2(6):458-463.
Abstract View: 362 times
PDF Download: 191 times