Antidiarrhoeal Studies of Methanol Leaf Extract of Cassia sieberiana Dc in Wistar Albino Rats
Asian Journal of Biochemistry, Genetics and Molecular Biology,
Aim: This study was aimed at evaluating the antidiarrhoeal effect methanol leaf extract of Cassia sieberiana.
Methodology: The leaf extract of Cassia sieberiana was obtained by extraction using methanol and subjected to phytochemical screening using standard methods. The anti-diarrhoeal effect of methanol leaf extract of Cassia sieberiana DC was investigated in Wistar Albino rats.
Results: The result of phytochemical screening revealed the presence of saponins, tannins, phenols, terpenoids, cardiac glycosides, steroids, flavonoids and anthraquinoes. The methanol extract significantly (P<.05) reduced the number of unformed faeces in castor oil induced diarrhoea in the rats. It also significantly (P<.05) reduced the gastrointestinal transit of activated charcoal as well as enteropooling in the rats used for the experiment was significantly reduced (P<.05) in the groups treated with 500 mg/kg and 750 mg/kg.
Conclusion: Based on the findings of this research, the methanol leaf extract of Cassia sieberiana possess anti-diarrheal activity and therefore validates its use in traditional medicine for the treatment of diarrhoea.
- Cassia sieberiana
- castor oil
- charcoal meal
How to Cite
Nigam Y, Knight J, Williams N. Gastrointestinal tract 5: The anatomy and functions of the large intestine. Nursing Times. 2019;115(10):50-3.
Schiller LR. Evaluation of chronic diarrhea and irritable bowel syndrome with diarrhea in adults in the era of precision medicine. American Journal of Gastroenterology. 2018;113(5):660-669.
Acharya D, Singh JK, Adhikari M, Gautam S, Pandey P, Dayal V. Association of water handling and child feeding practice with childhood diarrhoea in rural community of Southern Nepal. Journal of Infection and Public Health. 2018;11(1):69-74.
Leung DT, Chisti MJ, Pavia AT. Prevention and control of childhood pneumonia and diarrhea. Pediatric Clinics. 2016;63(1): 67-79.
Jamshidi-Kia F, Lorigooini Z, Amini-Khoei H. Medicinal plants: Past history and future perspective. Journal of Herbmed Pharmacology. 2018;7(1).
World Health Organization. Antimicrobial resistance and primary health care. World Health Organization; 2018.
Daniyal M, Akram M, Zainab R, Munir N, Shah SM, Liu B, Wang W, Riaz M, Jabeen F. Progress and prospects in the management of psoriasis and developments in phyto‐therapeutic modalities. Dermatologic Therapy. 2019; 32(3):e12866.
Edeoga HO, Okwu DE, Mbaebie BO. Phytochemical constituents of some Nigerian medicinal plants. African Journal of Biotechnology. 2005;4(7):685-8.
Sofowora A. Medicinal plants and traditional medicinal in Africa 2nd Edition. Sunshine House, Ibadan, Nigeria; 1993.
Trease GE, Evans WC. Pharmacognosy. 13th Edition, Bailere Traiadal, London. 1989;69.
Harborne JB. Phytochemical methods: A guide to modern techniques of plant analysis. Chapman and Hall Ltd., London. 1973;279.
Haque A, Zaman A, Hossain M, Sarker I, Islam S. Evaluation of antidiarrhoeal and insecticidal activities of ethanol extract and its fractions of Dendrophthoe falcata (L.) leaves. International Journal of Pharmaceutical Sciences and Research. 2014;5(9):3653.
Islam AM, Uddin ME, Chowdhury MA, Rahman MM, Habib MR, Rahman MA. In vivo antidiarrheal and cytotoxic potential of different fractions of Pandanus foetidus leaves. Am J Biomed Sci. 2013;5(3):208-16.
Sini JM, Umar IA, Anigo KM, Stantcheva I, Bage EN, Mohammed R. Antidiarrhoeal activity of aqueous extract of Combretum sericeum roots in rats. African Journal of Biotechnology. 2008;7(17).
Mascolo N, Izzo AA, Autore G, Barbato F, Capasso F. Nitric oxide and castor oil-induced diarrhea. Journal of Pharmacology and Experimental Therapeutics. 1994; 268(1):291-5.
Takem LP, Lawal BA, Lennox JA. Anti-diarrhoeagenic properties of aqueous extract of Phragmanthera capitata S. Balle in albino rats. European Journal of Medicinal Plants. 2014;12:743-52.
Archer MA, Agyei A, Mintah S, Adjei P, Kumadoh D, Asiedu-Larbi J. Medicinal uses of Cassia sieberiana; A review. Int J Sci Basic Appl Res. 2019;48:161-80.
Abdulrahman FI. Studies on the chemical contents and pharmacological activities of the root-bark extract of Vitex doniana (Black Plum). D Thesis, University of Maiduguri, Nigeria; 2004.
Dash PR, Raihan SZ, Ali MS. Ethnopharmacological investigation of the spice Kaempferia galanga. Lambert Academic Publishing, German. 2013;50: 87.
Kaur R, Bhaskar T. Potential of castor plant (Ricinus communis) for production of biofuels, chemicals and value-added products. In Waste Biorefinery. Elsevier. 2020;269-310.
Sagar L, Sehgal R, Ojha S. Evaluation of antimotility effect of Lantana camara L. var. acuelata constituents on neostigmine induced gastrointestinal transit in mice. BMC Complementary and Alternative Medicine. 2005;5(1):1-6.
Yacob T, Shibeshi W, Nedi T. Antidiarrheal activity of 80% methanol extract of the aerial part of Ajuga remota Benth (Lamiaceae) in mice. BMC Complementary and Alternative Medicine. 2016;16(1): 1-8.
Otshudi AL, Vercruysse A, Foriers A. Contribution to the ethnobotanical, phytochemical and pharmacological studies of traditionally used medicinal plants in the treatment of dysentery and diarrhoea in Lomela area, Democratic Republic of Congo (DRC). Journal of Ethnopharmacology. 2000;71(3):411-23.
Gahlawat DK, Jakhar S, Dahiya P. Murraya koenigii (L.) Spreng: An ethnobotanical, phytochemical and pharmacological review. Journal of Pharmacognosy and Phytochemistry. 2014;3(3):109-19.
Misra A, Srivastava S, Srivastava M. Evaluation of anti diarrheal potential of Moringa oleifera (Lam.) leaves. Journal of Pharmacognosy and Phytochemistry. 2014;2(5).
Zahan S. Evaluation of phytochemical and pharmacological properties of seeds of Momordica charantia. Avicenna Journal of Phytomedicine. 2020;10(5):448.
Yakubu MT, Amoniyan OD, Mohammed MO, Assin CI, Abubakar JO, Salimon SS, Omar SA. Anti-diarrhoeal activity of aqueous extract of Cochlospermum planchonii (Hook Fx. Planch) leaves in female Wistar rats. Journal of Medicinal Plants for Economic Development. 2020; 4(1):8.
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