Asian Journal of Biochemistry, Genetics and Molecular Biology

  • About
    • About the Journal
    • Submissions & Author Guideline
    • Accepted Papers
    • Editorial Policy
    • Editorial Board Members
    • Reviewers
    • Propose a Special Issue
    • Printed Hard copy
    • Subscription
    • Membership
    • Publication Ethics and Malpractice Statement
    • Digital Archiving
    • Contact
  • Archives
  • Indexing
  • Publication Charge
  • Submission
  • Testimonials
  • Announcements
Advanced Search
  1. Home
  2. Archives
  3. 2021 - Volume 8 [Issue 3]
  4. Review Article

Submit Manuscript


Subscription



  • Home Page
  • Author Guidelines
  • Editorial Board Member
  • Editorial Policy
  • Propose a Special Issue
  • Membership

Promiscuous Bioactivty of Phytochemicals

  • Ogochukwu Jennifer Umezinwa
  • Muhammad Alfa Ma’ali
  • Mohammed Yakubu Manbe
  • Ugwu Obiora Celestine
  • Nwankwo Ukechi Joy
  • Augustine Odibo
  • Abdullahi Alausa

Asian Journal of Biochemistry, Genetics and Molecular Biology, Page 28-44
DOI: 10.9734/ajbgmb/2021/v8i330195
Published: 15 July 2021

  • View Article
  • Download
  • Cite
  • References
  • Statistics
  • Share

Abstract


Phytochemicals are broad, largely studied compounds isolated from plants, generally regarded as a research compound than a nutritive molecule. In recent times, the pharmaceutical industry employs plants in the synthesis of novel drugs and active ingredients. These drugs and ingredients effectively manage neurodegenerative disorders, metabolic diseases, cancer, obesity, and other chronic-degenerative diseases. Although it still remains to be elucidated, the therapeutic strategies in synthesizing novel compounds. In this review, we discuss the major classification of phytochemicals, in addition to its biochemical mechanism of action. Furthermore, this study detailed the biosynthetic cascade of various phytochemicals and explained the anti-inflammatory and antioxidant mechanism on various disease processes. Therefore, this review discusses the multifunctional bioactivity of phytochemicals.


GRAPHICAL ABSTRACT


Capture2.PNG


Keywords:
  • Phytochemicals
  • COVID-19
  • neurodegenerative disease
  • cancer
  • obesity
  • Full Article – PDF
  • Review History

How to Cite

Umezinwa, O. J., Ma’ali, M. A., Manbe, M. Y., Celestine, U. O., Joy, N. U., Odibo, A., & Alausa, A. (2021). Promiscuous Bioactivty of Phytochemicals. Asian Journal of Biochemistry, Genetics and Molecular Biology, 8(3), 28-44. https://doi.org/10.9734/ajbgmb/2021/v8i330195
  • ACM
  • ACS
  • APA
  • ABNT
  • Chicago
  • Harvard
  • IEEE
  • MLA
  • Turabian
  • Vancouver

References

Bhullar KS, Rupasinghe HPV. Polyphenols: Multipotent therapeutic agents in neurodegenerative diseases. Oxidative Med. Cell. Longev;2013.
Available:https://doi.org/10.1155/2013/891748

Begum MM, Islam A, Begum R, Uddin MS, Rahman MS, Alam S, et al. Ethnopharmacological inspections of organic extract of Oroxylum indicum in rat models: A promising natural gift. evidence-based complement. Altern. Med. 2019;1–13.
Available:https://doi.org/10.1155/2019/1562038

Menza M, Dobkin RDF, Marin H, Mark MH, Gara M, Bienfait K, et al. The role of inflammatory cytokines in cognition and other non-motor symptoms of Parkinson’s disease. Psychosomatics. 2010;51:474–479.
Available:https://doi.org/10.1176/appi.psy.51.6.474

Alausa A, Adeyemi R, Olaleke B, Ismail A, Oyelere FS. Immune response to the pathogenesis of COVID-19 Infection: Possible mechanism of Nutrition (vitamins, supplement) and exercise. Pharm Biomed Res. 2020;6(2):81-92.
DOI: 10.18502/pbr.v6i(S2).5659

Damilola A Omoboyowa, Toheeb A Balogun, Onyeka S Chukwudozie, Victor N Nweze, Oluwatosin Saibu, Alausa Abdullahi. SARS-CoV-2 spike glycoprotein as inhibitory target for insilico screening of Natural compounds.
DOI: 10.33263/BRIAC116.1497414985

Alausa A, Ogundepo S, Olaleke B, Adeyemi R, Olatinwo M, Ismail A. Chinese nutraceuticals and physical activity; their role in neurodegenerative tauopathies. Chin Med. 2021;16(1):1.
DOI: 10.1186/s13020-020-00418-7

Newman DJ, Cragg GM. Natural products as sources of new drugs over the period 1981-2002. J Nat Prod. 2003;66:1022-37.

Heldt H, Piechulla B, Heldt F. Plant biochemistry, 4th ed.; United Kingdom: London. 2011;172–184.

Santos-Sánchez FN, Salas-Coronado R, Villanueva-Cañongo C, Hernández- Carlos B. Antioxidant compounds and their antioxidant mechanism, antioxidants. Edited by Emad Shalaby, Intechopen; 2019.

DOI: https://doi.org/10.5772/intechopen.85270

Bzowka M, Mitusinska K, Raczynska A, Samol A, Tuszynski JA, Gora A. Molecular dynamics simulations indicate the COVID-19 Mpro is not a viable target for small-molecule inhibitors design. BioRxiv, 2020.02.27.968008; 2020.

Available:https://doi.org/10.1101/2020.02.27.968008

Carradori S, Gidaro MC, Petzer A, Costa G, Guglielmi P, Chimenti P, et al. Inhibition of human monoamine oxidase: Biological and molecular modeling studies; 2016.

Uddin MS, Upaganlawar AB. Oxidative stress and antioxidant defense: Biomedical value in health and diseases. Nova Science Publishers, USA; 2019.

Anhe F, Roy D, Pilon G, Dudonne S, Matamoros S, Varin T. A polyphenol-rich cranberry extract protects from diet-induced obesity, insulin resistance, and intestinal inflammation in association with increased Akkermansia spp. population in the gut microbiota of mice. Gut. 2014;64(6):872–880.
DOI: 10.1136/gutjnl-2014-307142

Zahin M, Ahmad I, Gupta RC, Aqil F. Punicalagin and ellagic acid demonstrate antimutagenic activity and inhibition of benzo [a] pyrene induced DNA adducts. BioMed research international 2014;14:1-10.
Available:https://doi.org/10.1155/2014/467465

Xu Z, Peng C, Shi Y, Zhu Z, Mu K, Wang X, Zhu W. Nelfinavir was predicted to be a potential inhibitor of 2019-nCov main protease by an integrative approach combining homology modelling, molecular docking and binding free energy calculation. BioRxiv, 2020.01.27.921627; 2020.
Available:https://doi.org/10.1101/2020.01.27.921627

Mubarak A. Alamri, Ali Altharawi, Alhumaidi B Alabbas, Manal A Alossaimi, Safar M Alqahtani. Structure-based virtual screening and molecular dynamics of phytochemicals derived from Saudi medicinal plants to identify potential COVID-19 Therapeutics; Arabian Journal of Chemistry. 2020;13:7224–7234.
Available:https://doi.org/10.1016/j.arabjc.2020.08.004

Victor J Costela-Ruiz, Rebeca Illescas-Montes, Jose M Puerta-Puerta, Concepcion Ruiz, Lucia Melguizo-Rodriguez. SARS-CoV-2 infection: The role of cytokines in COVID-19 disease; Cytokine and Growth Factor Reviews. 2020;54:62–75.
Available:https://doi.org/10.1016/j.cytogfr.2020.06.001

Uddin MS, Kabir MT, Al Mamun A, Abdel-Daim MM, Barreto GE, Ashraf GM.. APOE and Alzheimer’s disease: evidence mounts that targeting APOE4 may combat Alzheimer’s pathogenesis. Mol. Neurobiol. 2019b;56:2450–2465.
Available:https://doi.org/10.1007/s12035-018-1237-z

Wang J, Song Y, Gao M, Bai X, Chen Z. Neuroprotective effect of several phytochemicals and its potential application in the prevention of neurodegenerative diseases. Geriatrics. 2016;1:29.
Available:https://doi.org/10.3390/geriatrics1040029

Mori T, Rezai-Zadeh K, Koyama N, Arendash GW, Yamaguchi H, Kakuda N, et al. Tannic acid is a natural β-Secretase inhibitor that prevents cognitive impairment and mitigates Alzheimer-like pathology in transgenic mice. J. Biol. Chem. 2012;287:6912–6927.
Available:https://doi.org/10.1074/jbc.M111.294025

Valenti D, De Rasmo D, Signorile A, Rossi L, de Bari L, Scala I. Epigallocatechin- 3-gallate prevents oxidative phosphorylation deficit and promotes mitochondrial biogenesis in human cells from subjects with Down’s syndrome. Biochim. Biophys. Acta - Mol. Basis Dis. 2013: 1832, 542–552. https://doi.org/10.1016/j.bbadis.2012.12.011.

Kato, Y., Ozawa, S., Miyamoto, C., Maehata, Y., Suzuki, A., Maeda, T., Baba, Y. Acidic extracellular microenvironment and cancer. Cancer cell international. 2013;13:89-96.
Available:https://doi.org/10.1186/1475-2867-13-89

Katoh M, Katoh M. WNT signaling pathway and stem cell signaling network. clinical cancer research. 2007;13:4042-4045.
DOI: 10.1158/1078-0432.CCR-06-2316

Wei R, Mao L, Xu P, Zheng X, Hackman RM, Mackenzie GG, Wang Y. Suppressing glucose metabolism with epigallocatechin-3-gallate (EGCG) reduces breast cancer cell growth in preclinical models. Food and function. 2018;9:5682-5696.
DOI: 10.1039/c8fo01397g

Tung NH, Du GJ, Yuan CS, Shoyama Y, Wang CZ. Isolation and chemo preventive evaluation of novel naphthoquinone compounds from Alkanna tinctoria. Anti-cancer drugs. 2013;24:1-13.
DOI: 10.1097/CAD.0000000000000017

Khan M, Giessrigl B, Vonach C, Madlener S, Prinz S, Herbaceck I, Hölzl C, Bauer S, Viola K, Mikulits W. Berberine and a berberis lycium extract inactivate Cdc25A and induce α-tubulin acetylation that correlate with HL-60 cell cycle inhibition and apoptosis. Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis. 2010;683:123-130.
DOI: 10.1016/j.mrfmmm.2009.11.001

Bauer TM, Patel MR, Infante JR. Targeting PI3 kinase in cancer. Pharmacology and therapeutics. 2015;146:53-60.
DOI: 10.1016/j.pharmthera.2014.09.006

Serra D, Paixão J, Nunes C, Dinis TC, Almeida LM. Cyanidin-3-glucoside suppresses cytokine-induced inflammatory response in human intestinal cells: Comparison with 5-aminosalicylic acid. 2013;PloS one 8:e73001.
DOI: 10.1371/journal.pone.0073001

Iqbal J, Abbasi BA, Mahmood T, Kanwal S, Ali B, Shah SA, et al. Plant-derived anticancer agents: A green anticancer approach. Asian Pac J Trop Biomed. 2017;7:1129-50.
DOI: 10.1016/j.apjtb.2017.10.016

Nishikawa S, Aoyama H, Kamiya M, Higuchi J, Kato A, Soga M, et al. Artepillin, a typical brazilian propolis derived component, induces brown-like adipocyte formation in C3H10T1/2 cells, primary inguinal white adipose tissue-derived adipocytes, and mice, PLoS One. 2016;11(9):e0162512.
DOI: 10.1371/journal.pone.0162512. eCollection 2016.

Jimenez-Gomez Y, Mattison JA, Pearson KJ, Martin-Montalvo A, Palacios HH, Sossong AM, et al. de Cabo, resveratrol improves adipose insulin signaling and reduces the inflammatory response in adipose tissue of rhesus monkeys on high-fat, high-sugar diet, Cell Metab. 2013;18 (4):533–545.
DOI: 10.1016/j.cmet.2013.09.004

Aggarwal BB. Targeting inflammation-induced obesity and metabolic diseases by curcumin and other nutraceuticals, Annu. Rev. Nutr. 2010;30(1):173–199.
DOI: 10.1146/annurev.nutr.012809.104755

Chou YC, Ho CT, Pan MH. Immature citrus reticulata extract promotes browning of beige adipocytes in high-fat diet-induced C57BL/6 mice, J. Agric. Food Chem. 2018;66(37):9697–9703.
DOI: 10.1021/acs.jafc.8b02719

Queipo-Ortuño MI, Boto-Ordóñez M, Murri M, Gomez-Zumaquero JM, Clemente-Postigo M, Estruch R. Influence of red wine polyphenols and ethanol on the gut microbiota ecology and biochemical biomarkers. Am. J. Clin. Nutr. 2012;95:1323–1334.
DOI: 10.3945/ajcn.111.027847
  • Abstract View: 473 times
    PDF Download: 132 times

Download Statistics

Downloads

Download data is not yet available.
  • Linkedin
  • Twitter
  • Facebook
  • WhatsApp
  • Telegram
Make a Submission / Login
Information
  • For Readers
  • For Authors
  • For Librarians
Current Issue
  • Atom logo
  • RSS2 logo
  • RSS1 logo


© Copyright 2010-Till Date, Asian Journal of Biochemistry, Genetics and Molecular Biology. All rights reserved.