Camparative Study of the Physical Parameters in DMBA Induced Oral Carcinoma Rat Model and Herbal Extract FED Oral Carcinoma Rat Model
A. Shukla *
Department of Zoology, Government Arts and Commerce College, Rau, Indore, India.
V. K. Sharma
Government Holkar Science College, Indore (M.P), India.
*Author to whom correspondence should be addressed.
Abstract
Cancer, a multifactorial disorder, arises due to defect in genetic makeup and exposure to unfavourable environmental conditions. Oral cancer, a life-threatening cancer worldwide, arises in the oral cavity due to ill-habits such as tobacco smoking and chewing. Monitoring body weight is an essential aspect of any preclinical study, including DMBA-induced oral carcinoma rat models and models with potential therapeutic interventions like Zingiber and piper feeding. Changes in body weight, feeding, water intake can provide valuable insights into the general health and physiological effects of the experimental conditions.
Keywords: Body weight, squamous cell carcinoma, phytochemicals, Zingiber officinale, piper nigrum, DMBA
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Attar E, Dey S, Hablas A, Seifeldin IA, Ramadan M, Rozek LS, Soliman AS. Head and neck cancer in a developing country: a population-based perspective across 8 years. Oral oncology. 2010;46(8):591-6.
Sung H, Ferlay J, Siegel RL, Laversanne M, Soerjomataram I, Jemal A, Bray F. Global cancer statistics 2020: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA: a cancer journal for clinicians. 2021; 71(3):209-49.
Prasad P, Hamed MS, Nahar P. A Comparison of Feulgen Stain and Acridine Orange to Stain Micronuclei in Shisha Smokers and Cigarette Smokers. Journal of Clinical Research in Dentistry. 2018; 1(1):1-3.
Demaria M, O'Leary MN, Chang J, Shao L, Liu S, Alimirah F, et al. Cellular senescence promotes adverse effects of chemotherapy and cancer relapse. Cancer discovery. 2017;7(2):165-76.
Kaushal N, Rao S, Ghanghas P, Abraham S, George T, D’souza S, et al. Usefulness of Ocimum sanctum Linn. in cancer prevention: An update. Anticancer plants: Properties and Application. 2018;1: 415-29.
Lal AS, Begum SK, Bharadwaj SS, Lalitha V, Vijayalakshmi J, Paul SF, Maddaly R. Bleomycin-induced genotoxicity in vitro in human peripheral blood lymphocytes evidenced as complex chromosome-and chromatid-type aberrations. Toxicology in Vitro. 2019;54:367-74.
Russo M, Moccia S, Luongo D, Russo GL. Senolytic flavonoids enhance type-I and type-II cell death in human radioresistant colon cancer cells through AMPK/MAPK pathway. Cancers. 2023;15(9):2660.
Otsuru M, Ota Y, Yanamoto S, Okura M, Umeda M, Kirita T, et al. A multicenter retrospective study of elective neck dissection for T1-2N0M0 tongue squamous cell carcinoma: analysis using propensity score-matching. Annals of Surgical Oncology. 2019;26:555-63.
Banning A, Kipp A, Brigelius-Flohé R. Glutathione peroxidase 2 and its role in cancer. Selenium: Its molecular biology and role in human health. 2012:271-82.
Fadlullah MZH, Chiang IK-N, Dionne KR, San Yee P, Gan CP, Sam KK, et al. Genetically-defined novel oral squamous cell carcinoma cell lines for the development of molecular therapies. Oncotarget. 2016;7(19):27802.
Unnikrishnan M, Kuttan R. Cytotoxicity of extracts of spices to cultured cells; 1988.
Manimaran A, Buddhan R, Manoharan S. Emodin downregulates cell proliferation markers during DMBA induced oral carcinogenesis in golden Syrian hamsters. African Journal of Traditional, Complementary and Alternative Medicines. 2017;14(2):83-91.
Tsui DWY, Murtaza M, Wong ASC, Rueda OM, Smith CG, Chandrananda D, et al. Dynamics of multiple resistance mechanisms in plasma DNA during EGFR‐targeted therapies in non‐small cell lung cancer. EMBO molecular medicine. 2018;10(6):e7945.
Yeh LY, Chou CH, Liu CJ, Lin SC, Chang KW. miR-372 enhances tumorigenesis and drug resistance in oral carcinoma by targeting ZBTB7A transcription factor. Cancer Research. 2018;78 (13_Supplement):479.
Murata H, Tsuji S, Tsujii M, Fu H, Tanimura H, Tsujimoto M, et al. Helicobacter bilis infection in biliary tract cancer. Alimentary pharmacology & therapeutics. 2004;20:90-4.
Bertoli C, Skotheim JM, De Bruin RA. Control of cell cycle transcription during G1 and S phases. Nature reviews Molecular cell biology. 2013;14(8):518-28.
Carnelio S, Rodrigues GS, Shenoy R, Fernandes D. A brief review of common oral premalignant lesions with emphasis on their management and cancer prevention. Indian Journal of Surgery. 2011;73:256-61.
Choi B, Jeong DS, Kim S, Rohde C, Choi S, Oh JH, et al. Resistive switching mechanism of TiO2 thin films grown by atomic-layer deposition. Journal of applied physics. 2005;98(3).
Mandal D, Sarkar T, Chakraborty R. Critical review on nutritional, bioactive, and medicinal potential of spices and herbs and their application in food fortification and nanotechnology. Applied biochemistry and biotechnology. 2023;195(2):1319-513.
Manoharan S, Rajasekaran D, Prabhakar MM, Karthikeyan S, Manimaran A. Modulating effect of Enicostemma littorale on the expression pattern of apoptotic, cell proliferative, inflammatory and angiogenic markers during 7, 12-dimethylbenz (a) anthracene induced hamster buccal pouch carcinogenesis. Toxicology international. 2015;22(1):130.
Xiong H, Yang Y, Yang K, Zhao D, Tang H, Ran X. Loss of the clock gene PER2 is associated with cancer development and altered expression of important tumor-related genes in oral cancer. International journal of oncology. 2018;52(1):279-87.
Al-Khayri JM, Upadhya V, Pai SR, Naik PM, Al-Mssallem MQ, Alessa FM. Comparative Quantification of the Phenolic Compounds, Piperine Content, and Total Polyphenols along with the Antioxidant Activities in the Piper trichostachyon and P. nigrum. Molecules. 2022;27(18):5965.
Tanaka T, Tanaka T, Tanaka M. Potential cancer chemopreventive activity of protocatechuic acid. Journal of Experimental & Clinical Medicine. 2011; 3(1):27-33.
Ranasinghe K, Premarathna A, Mahakapuge T, Wijesundera K, Ambagaspitiya A, Jayasooriya A, et al. In vivo anticancer effects of Momordica charantia seed fat on hepatocellular carcinoma in a rat model. Journal of Ayurveda and Integrative Medicine. 2021; 12(3):435-42.
Takiar V, Garden AS, Ma D, Morrison WH, Edson M, Zafereo ME, et al. Reirradiation of head and neck cancers with intensity modulated radiation therapy: outcomes and analyses. International Journal of Radiation Oncology* Biology* Physics. 2016;95(4):1117-31.
Kandil DH, Cooper K. Glypican-3: a novel diagnostic marker for hepatocellular carcinoma and more. Advances in anatomic pathology. 2009;16(2): 125-9.
Siegel RL, Miller KD, Jemal A. Cancer statistics CA: a cancer journal for clinicians. 2018;68(1):7-30.