Emerging Role of Probiotics in Advancement of Combating Physical Abnormalities and Diseases: A Systematic Perspective Analysis
Mst. Tania Khatun
Department of Pharmacy, Islamic University, Kushtia-7003, Bangladesh.
Forkanul Hoque
Department of Pharmacy, Islamic University, Kushtia-7003, Bangladesh.
Naeema Salatia Hoque
Department of Biotechnology and Genetic Engineering, Islamic University, Kushtia-7003, Bangladesh.
Md. Sakhawat Hossain
Department of Biotechnology and Genetic Engineering, Islamic University, Kushtia-7003, Bangladesh.
Md. Ashraful Alam
Department of Applied Chemistry and Chemical Engineering, Islamic University, Kushtia-7003, Bangladesh.
Sabrina Afrin
Department of Applied Chemistry and Chemical Engineering, Islamic University, Kushtia-7003, Bangladesh.
Tanjina Nasrin Eva
Department of Applied Chemistry and Chemical Engineering, Islamic University, Kushtia-7003, Bangladesh.
Rahima Tanbin Tama
*
Department of Biotechnology and Genetic Engineering, Islamic University, Kushtia-7003, Bangladesh.
*Author to whom correspondence should be addressed.
Abstract
Probiotics are live microorganisms, primarily bacteria that give the host health benefits when given in sufficient amounts. It works in various defensive mechanisms, including releasing antimicrobial compounds, competitive adhesion to the mucosa and epithelium, fortifying the gut epithelial barrier and regulating the immune system. Probiotics have a considerable effect in reducing allergies and gastrointestinal problems like diarrhoea and ulcers. Probiotics are quite beneficial for managing and preventing complex diseases including diabetes, cardiovascular diseases, anaemia, urogenital diseases, dental caries, URTI, cancers and various abnormalities like obesity, depression, etc. Nowadays, Antibiotic resistance is a global challenge associated with high morbidity and mortality. The current lack of efficacious treatments necessitates the creation of innovative therapeutic approaches and substitute antimicrobial therapies. So, natural products or probiotics would be a better option for treating human health. Therefore, we systematically reviewed the sources, including Google Scholar, PubMed, Science Direct, Jstor and Base; studies only about human health were included here. All types of animal diseases and articles before 1990 are excluded. A total of 6,410 articles were identified and 300 articles were taken for further evaluation based on context. However, Probiotics have already become a successful therapeutic intervention strategy among physicians. This investigation covers a comprehensive overview of the current state of probiotic research which comprises a wide range of topics including sourcing, mode of action, probiotic strains, isolating procedures and the role of probiotics.
Graphical abstract
Keywords: Abnormality, diseases, defensive mechanism, probiotics