Evaluation of Lipid Profile and Atherogenic Index of Plasma in Patients with Type 2 Diabetes (AIP = log TG/HDL-c)
Djite Moustapha *
Laboratory of Pharmaceutical Biochemistry, Faculty of Medicine, Pharmacy, Cheikh Anta Diop University, Dakar, Senegal and Laboratory of Biochemistry, University Hospital Fann, Dakar, Senegal.
Barry Nene Kesso Oumou
Laboratory of Pharmaceutical Biochemistry, Faculty of Medicine, Pharmacy, Cheikh Anta Diop University, Dakar, Senegal and Laboratory of Biochemistry, University Hospital Fann, Dakar, Senegal.
Kandji Pape Matar
Laboratory of Biochemistry, University Hospital Fann, Dakar, Senegal.
Sagne René Ngor
Laboratory of Biochemistry, University Hospital Fann, Dakar, Senegal.
Ndour El Hadji Malick
Laboratory of Pharmaceutical Biochemistry, Faculty of Medicine, Pharmacy, Cheikh Anta Diop University, Dakar, Senegal.
Gueye-Tall Fatou
Laboratory of Pharmaceutical Biochemistry, Faculty of Medicine, Pharmacy, Cheikh Anta Diop University, Dakar, Senegal.
Thioune Ndeye Marieme
Laboratory of Biochemistry, University Hospital Fann, Dakar, Senegal.
T. Sagna-Bassene Helene Ange
Laboratory of Pharmaceutical Biochemistry, Faculty of Medicine, Pharmacy, Cheikh Anta Diop University, Dakar, Senegal.
Coly-Gueye Najah Fatou
Diamniadio Children Hospital, Dakar, Sénégal.
Doupa Dominique
Department of Medical Biochemistry, Saint-Louis University, Saint-Louis, Senegal.
Ndiaye-Diallo Rokhaya
Laboratory of Pharmaceutical Biochemistry, Faculty of Medicine, Pharmacy, Cheikh Anta Diop University, Dakar, Senegal.
Ndour-Mbaye Maimouna
Department of Internal Medicine, Abass Ndao Hospital Center, Dakar, Senegal.
Cisse Aynina
Laboratory of Pharmaceutical Biochemistry, Faculty of Medicine, Pharmacy, Cheikh Anta Diop University, Dakar, Senegal.
Diop Pape Amadou
Laboratory of Pharmaceutical Biochemistry, Faculty of Medicine, Pharmacy, Cheikh Anta Diop University, Dakar, Senegal.
Lopez-Sall Philomène
Laboratory of Pharmaceutical Biochemistry, Faculty of Medicine, Pharmacy, Cheikh Anta Diop University, Dakar, Senegal.
Gueye Papa Madieye
Laboratory of Pharmaceutical Biochemistry, Faculty of Medicine, Pharmacy, Cheikh Anta Diop University, Dakar, Senegal and Laboratory of Biochemistry, University Hospital Fann, Dakar, Senegal.
*Author to whom correspondence should be addressed.
Abstract
Aims: The objective of our study was to evaluate the lipid profile and the plasma atherogenicity index obtained from the log (TG / HDL-c) in diabetics patients.
Study Design: This is a comparative and analytical study.
Place and Duration of Study: Sample: MARC SANKALE Centre at the Abass Ndao Hospital in Dakar (Senegal), CHNU/Fann Biochemistry Laboratory, from June 2018 to November 2019.
Controls: For each patient, a witness of the same sex and the same age ± 2 years was recruited.
Methodology: The lipid balance parameters were assayed using enzymatic techniques with the Cobas c311 system (Roche Diagnostics, Switzerland). Plasma atherogenicity indices for each patient were calculated (CT / HDL-c, LDL / HDL-c and Log (TG / HDL-c)).
Data analysis was performed using XLSTAT software and a p value <0.05 was considered to be a statistically significant difference.
Results: Our study concerned 100 subjects with type 2 diabetes. The average age was 50.5 ± 10.80 years old and the sex ratio was 0.58. Evaluation of lipid parameters had shown an increase in diabetic subjects compared to controls for total cholesterol (2.30 g / l) and LDL-cholesterol (1.40 g / l) with significant differences (p < 0.001). We also found that 11% of patients had a CT / HDL-c ratio > 4.5, while 8% had an LDL-c / HDL-c ratio > 3.5 and 26% of patients had a log (Tg / HDL- c) > 0.21.
Conclusion: Lipid disturbances constitute significant abnormalities in type 2 diabetic subjects and would predispose them to cardiovascular complications. However, IAP = log (TG / HDL-c) could be considered the most sensitive predictor of cardiovascular risk.
Keywords: Lipids, atherogenic risk, diabetes, plasma atherogenicity index.