Open Access Short communication

Is There Any Connection between Urine pH with Freckles?

Muhammad Imran Qadir, Aqsa Asghar

Asian Journal of Biochemistry, Genetics and Molecular Biology, Page 25-27
DOI: 10.9734/ajbgmb/2020/v4i130098

The aim of the present study was to show the relationship between urine pH and freckles. We asked about this to 100 participants in the research. These participants were the students of Bahauddin Zakariya University. By urine sample, we analyze the acidity or alkalinity of urine. The test for checking the acidity or alkalinity of urine is also called a urine pH test. A urine test shows the acidic or basic result if we take medicine our diet or many diseases. Freckles are a small brown spot on the surface of the skin. They only not found on the skin of the children. Freckles have a different color like dark brown, sometimes black moles type.  It was concluded from the result that the test was non-significant because there was no link between urine pH and freckles.

Open Access Original Research Article

Phenotypic and Genetic Parameter Estimates for Local Guinea Fowl Production and Some Other Traits

Addison Doudu, Serekye Yaw Annor, James Kwame Kagya-Agyemang, Godson Aryee Zagbede, Clement Gyeabour Kyere

Asian Journal of Biochemistry, Genetics and Molecular Biology, Page 1-12
DOI: 10.9734/ajbgmb/2020/v4i130095

This study on indigenous Guinea fowls in Ghana was undertaken to estimate genetic variation and heritability of traits in these birds. The study was conducted at the Poultry Section of the Animal farm of the Department of Animal Science Education, University of Education, Winneba, Mampong-Ashanti campus, Ghana, from 2015 to 2018. The data used in the present experiment were collected from six hundred keets (300 males and 300 females) produced from randomly selecting and mating 110 dams and 22 sires and consisted of 780 records collected over a period of 3 years. The genetic parameters were estimated using sire-son, sire-daughter and dam-daughter regression analysis.  Body weight and 8-month weight gain showed the greatest additive genetic variation, with survival, docility, dressing percentage, age at first egg, egg weight, egg number, fertility, hatchability traits, feed intake and FCR showing relatively low additive genetic variation.  Moderate to high heritability estimates were obtained for body weight, weight gain at ages 1day to 2 months, 2-4 months in females, 4-6 months in males, docility, feed intake in females and feed conversion ratio in both males and females. Similarly, moderate to high heritability estimates were also obtained for age at first egg, egg weight and egg numbers. However, all other parameters considered in this study had low heritability estimates. This study concludes that, the results could be used to initiate Guinea fowl selection breeding programmes.

Open Access Original Research Article

Frequency of Janus Kinas 2V617F (JAK2V617F) Mutation among Children with Type 1 Diabetes Mellitus

Nadia Farouk Zekry, Omyma Galal, Mohammed H. Hassan, Hala M. Sakhr, Rana Toghan

Asian Journal of Biochemistry, Genetics and Molecular Biology, Page 13-17
DOI: 10.9734/ajbgmb/2020/v4i130096

Background and Objectives: Type 1 Diabetes mellitus (T1DM) is a disorder of glucose homeostasis results from the destruction of β- cells of the pancreas with subsequent insulin deficiency and hyperglycemia. Acquired mutation (V617F) affecting the JAK2 gene disrupts the auto-inhibition of JAK2 and results in constitutive activation of the Janus Kinase 2(JAK2)/signal transducer and activator of transcription (STAT) pathway. Once activated, the JAK/STAT pathway stimulates cell proliferation, differentiation, migration and apoptosis critically involved in growth control. Studies investigating the possible role of Janus kinas 2V617F (JAK2V617F) mutation and risk of T1DMor development of diabetic complications among such children are very few. So we aimed in this pilot study to estimate the relative frequency of Janus kinas 2V617F (JAK2V617F) mutation among a sample of children with T1DM.

Patients and Methods: This cross-sectional study included 25 Egyptian children with T1DM. Full clinical evaluation, routine laboratory investigations including kidney function, RBG, HbA1C and A/C ratio were done. Determination of JAK 2v617f gene mutation was performed using real time-PCR.

Results: The included diabetic children were 15 males and 10 females. Their mean random blood glucose was 272mg/dl±33 SD. Two cases exhibited mutation in the form of heterozygous type (Aa) representing 8% of the total included diabetic children and the remaining 23 (92%) diabetic children showed normal wild alleles (AA). There was a non-significant correlation between the glycemic control and the presence of JAK 2v617f gene mutation, p˃0.05.

Conclusions: JAK 2v617f gene mutation present in a small percentage of non-complicated T1DM with lack of its correlation with the glycemic control.

Open Access Original Research Article

Effect of Dietary Diversity and Dietary Behaviors on Nutritional Status of Selected Young Women from Dhaka City, Bangladesh

Mohammad Rahanur Alam, Lincon Chandra Shill, Sompa Reza, Naimun Nahar, Roksana Kader, Md. Aminul Haque Bhuyan

Asian Journal of Biochemistry, Genetics and Molecular Biology, Page 18-24
DOI: 10.9734/ajbgmb/2020/v4i130097

Aims: A balanced diet includes a variety of foods from different food groups that are essential for healthy growth and development. The primary goal of this paper was to assess the outcome of dietary diversity and its related factors on nutritional status among young girls in Dhaka city.

Study Design: The study was a cross-sectional study.

Methodology: The total number of 100 young girls aged 18 to 25 from four selected areas of Dhaka city were interviewed by a structured questionnaire on dietary diversity, dietary behavior, socio-demographic status and different anthropometric assessment were done using standard technique.

Results: Our study revealed that more than half (55%) of the participants had normal nutritional status, and 12% of the young women were under-weight. The prevalence of overweight and obese were respectively 26% and 7%. The study exhibited a significant correlation between nutritional status with different dietary habits and various food groups. 45% of the study participants had an acceptable dietary diversity score and there was no significant association between dietary diversity score and BMI of young girls.

Conclusion: The nutritional status of the study participants depicted a portrait of the double burden of malnutrition, and the overall nutritional status is shifting more towards overweight and obesity. It also indicates that the dietary diversity score of the selected young girls of Dhaka city is satisfactory, although their knowledge about dietary behavior needs to be improved.

Open Access Review Article

Defective Ion Channel in Cystic Fibrosis: Current Development in Treatment of Cystic Fibrosis

Ngoga Godfrey, M. M. Ganyam, G.O. Ibiang, C. A. Difa, Nelson Christian

Asian Journal of Biochemistry, Genetics and Molecular Biology, Page 28-34
DOI: 10.9734/ajbgmb/2020/v4i130099

Cystic fibrosis is an inherited disorder that causes severe damage to the lungs, digestive system and other organs in the body. Cystic fibrosis transmembrane conductance regulator (CFTR) is involved in the production of mucus, sweat and digestive juices. These secreted fluids are normally thin and slippery. But in people with cystic fibrosis, a defective gene in CFTR causes the secretions to become sticky and thick. Instead of acting as a lubricant, the secretions plug up tubes, ducts and passage ways, especially in the lungs and pancreas. This mucus leads to the formation of bacterial microenvironments known as biofilms (a niche that harbors bacteria; Staphylococcus aureus, Haemophilus influenzae, and Pseudomonas aeruginosa ) that are difficult for immune cells and antibiotics to penetrate. Viscous secretions and persistent respiratory infections repeatedly damage the lung by gradually remodeling the airways, which makes infection even more difficult to eradicate. CFTR, a Cl selective ion channel, is a prototypic member of the ATP-binding cassette transporter super family that is expressed in several organs. Understanding how these complexes regulate the intracellular trafficking and activity of CFTR provides a unique insight into the aetiology of cystic fibrosis and other diseases associated to it. Cystic fibrosis patients exhibit lung disease consistent with a failure of innate airway defense mechanisms. The link between abnormal ion transport, disease initiation and progression is not fully understood, but airway mucus dehydration seems paramount in the initiation of CF lung disease. New therapies are currently in development that target the ion transport defects in CF with the intention of rehydrating airway surfaces.